N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in org-anic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups. N,N-Dimethylformamide is a polar solvent commonly used in org-anic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.
Application
N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4'-(6-O hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various org-anic reduction reactions.
DMF has been used as a solvent in the following processes:
- Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide.
- Synthesis of phosphine-FLAG®, a detection reagent for metabolic labeling of glycans.
- Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar.
- Solvent for many hydrophobic org-anic compounds.